Adele K. Addington, PhD

Lab Manager

Involvement of proteinases in normal and abnormal physiology
Interactions between proteinases and carbohydrates in normal and disease states
Role of apoptosis and apoptotic proteinases in disease states
Development of enzyme-based biosensors
Normal metabolic changes in fetal and neonatal development

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Martje Tönjes, Sebastian Barbus, Yoon Jung Park, Wei Wang, Magdalena Schlotter, Anders M Lindroth, Sabrina V Pleier, Alfa H C Bai, Daniela Karra, Rosario M Piro, Jörg Felsberg, Adele Addington, Dieter Lemke, Irene Weibrecht, Volker Hovestadt, Claudio G Rolli, Benito Campos, Sevin Turcan, Dominik Sturm, Hendrik Witt, Timothy A Chan, Christel Herold-Mende, Ralf Kemkemer, Rainer König, Kathrin Schmidt, William-Edmund Hull, Stefan M Pfister, Manfred Jugold, Susan M Hutson, Christoph Plass, Jürgen G Okun, Guido Reifenberger, Peter Lichter, Bernhard Radlwimmer ; Nature Medicine, (2013) 19:901–908.

Quantitation of Cathepsins B and L in Cells, Ruye Xing, Adele K. Addington, and Robert W. Mason; Biochemical Journal, (1998) 332:499-505.

Inactivation of Human Lung Tryptase: Evidence for a Re-Activatable Tetrameric Intermediate and Active Monomers, Adele K. Addington and David A. Johnson; Biochemistry 35:13522-13518 (1996).

Annual Meeting of the American Society of Biochemists and Molecular Biologists; April 2007; Washington, D.C.; attended biochemistry education sessions and career development seminars, served as undergraduate poster judge;

Received ASBMB Undergraduate Faculty Travel Award ($500).

233rd National Meeting of the American Chemical Society Annual Meeting; Chicago, IL; April 2007; delivered oral paper.

15th Annual Undergraduate and High School Poster Session, Virginia Blue Ridge Section of the American Chemical Society, Radford, Virginia; April, 2007; oversaw 1 student poster presentation.

14th Annual Undergraduate and High School Poster Session, Virginia Blue Ridge Section of the American Chemical Society, Radford, Virginia; April, 2006; oversaw 2 student poster presentations.

1994, Ph.D., Virginia Tech, Biochemistry
Thesis: The synthesis of a protein-cysteine proteinase inhibitor complex for the study of endosome-lysosome fusion

1990, B.S., Virginia Tech, Biochemistry and Nutrition
Summa cum laude

American Medical Writers Association: 2007- 2011: completed requirements for multidisciplinary certificate

American Society for Biochemistry and Molecular Biology: August 2001- 2012

American Chemical Society: September 2000 –2008

American Academy for the Advancement of Science: 1991- 2006

Phi Kappa Phi: 1990 – present

Iota Sigma Pi National Honor Society for Women in Chemistry: 1998-present

Council on Undergraduate Research: June 2003-June 2005

National Science Teachers Association: May 2001- 2003

Adele Addington

1981 Kraft Drive
1003 ILSB