Siobhan Craige

Siobhan Craige, PhD

Assistant Professor

Graduate Program Faculty

The overall goal of my research program is to elucidate the mechanisms by which diet and exercise influence vascular health and the prevention of cardio-metabolic disease. Specifically, I focus on signaling pathways in endothelial cells, which are the monolayer of cells that line the lumen of the vasculature. This highly specialized cell layer is responsible for rapidly reacting to changes in organ demand, such as nutrient deprivation or low oxygen. While diet and exercise are known to be important for the prevention of cardio-metabolic diseases, the molecular mechanisms underpinning their benefits are only beginning to come to light. My current research has identified a critical role for reactive oxygen species (ROS) signaling in adaptive responses to diet and exercise, and understanding the molecular pathways that respond to these will pave the way for targeted therapies in cardio-metabolic disease.

  • Association for Women in Science, 2015-present
  • American Society for Biochemistry and Molecular Biology, 2011-present
  • Society of Free Radical Biology and Medicine, 2010-present
  • American Heart Association, 2008-present
  • NIAMS Reactive oxygen species drive muscle metabolism, K01 AR073332-01: 2019-2024
  • Oklahoma Nathan Shock Center Pilot Project Award, 2017 
  • NIH National Research Service Award, Postdoctoral: 1F32HL099282, 2010-2013
  • NIH National Research Service Award, Predoctoral: 2T32EY0070920, 2001-2006
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Mentored Research Scientist Development Award (K01), 2019
  • New Faculty Mentoring Project Grant, 2018
  • CALS Global Faculty Initiative Travel Award, 2018
  • Pilot Project Award, Oklahoma Nathan Shock Center of Excellence in the Biology of Aging to investigate redox changes in Nox4 with exercise, 2017
  • National Research Service Award Recipient (NRSA) NHLBI 2010-2013
  • Travel Award Winner, Society of Free Radical Biology and Medicine, Orlando FL, 2010
  • Achievement Reward for College Scientists (ARCS) Fellowship, Emory University, 2005-2007
  • Donald B. McCormick Award for Research Contributions to Nutrition, Emory University, 2005

2007, Ph.D., Emory University, Biochemistry
Thesis: Oxidative Stress in Aging and Age-Related Disease: Determinants of Plasma Cysteine and Glutathione Redox State

1999, B.S., Emory University, Biology