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Siobhan Craige, PhD

Assistant Professor
  • Focus area(s): Exercise metabolism; redox signaling in health and disease; vascular influence on diet and exercise
A Virginia Tech HNFE faculty member stands against a white wall for a headshot.
1012 ILSB
craigesm@vt.edu
540-231-4149
  • Graduate Program Track(s): Molecular & Cellular Science
The Craige Lab

Education

Ph.D., Biochemistry, Emory University

B.S., Biology, Emory University

Experience

2018 – present: Assistant Professor, Department of HNFE, Virginia Polytechnic Institute and State University, Blacksburg, VA

2017 – 2018: Assistant Professor, University of Massachusetts Medical School, Worcester, MA

2014 – 2017: Instuctor, University of Massachusetts Medical School, Worcester, MA

Selected Major Awards

  • 2023 – University Libraries Collaborative Research Grant
  • 2023 – HNFE S.J. Ritchey Fund for Faculty Pilot Studies
  • 2022 – VT Office of Undergraduate Research Faculty Grant + Supplement    
  • 2021 – VT CALS Global Faculty Partnership Initiative Award (Institute of Physiology CAS)
  • 2019 – 2024 – NIAMS K01 AR073332 (5 years)     
  • 2018 – VT CALS Global Faculty Partnership Initiative Award (Karolinska)
  • 2017 – Oklahoma Nathan Shock Center Pilot Project Award

Program Focus

The central focus of the Craige Lab's research is understanding how cells/tissues communicate with each other to sense and respond to environmental changes (e.g., diet, exercise, disease, etc.). Although the significance of diet and exercise for health is widely recognized, the intricate molecular signaling underlying their effects remains unclear. The Craige Lab areas of specific focus include understanding the intercellular communication between endothelial cells and skeletal muscle cells in response to exercise stress, investigating the impact of intra- and inter-cellular redox signaling on age-related alterations in skeletal muscle, and examining the influence of high-fat diet-induced stress on sexually dimorphic redox responses in bone.

The Craige Lab

NIH Bibliography

Selected Recent Publications

For full list of publications: PubMed

Current Funding:

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R03: Endothelial Signaling in Exercise Metabolism
  • NIAMS R01: Endothelial Reactive Oxygen Species in Exercise Metabolism
  • CeZAP Pilot Funding: Leveraging Reactive Oxygen Species for Antiviral Therapy Against Chronic Alphavirus Disease

Previous Funding:

  • NIAMS R56: Endothelial Reactive Oxygen Species in Exercise Metabolism
  • Virginia Tech SJ Ritchey Research: Development of an undergraduate research project to investigate intercellular exercise signaling in cell culture.
  • NIAMS K01: Reactive oxygen species drive muscle metabolism
  • VT University Libraries Collaborative Research Grant: Developing a Canvas resource to promote undergraduate wet lab researcher success
  • VT Office of Undergraduate Research Faculty Grant: Student-Led Team Approach to Gene and Protein Expression Investigations
  • NIAMS F31 to graduate student Kalyn Specht (previous Craige Lab PhD student): NOX4 mediates the metabolic stress response in skeletal muscle
  • Pre-doctoral American College of Sports Medicine (ACSM) to Kalyn Specht: NOX4 mediates mitochondrial remodeling in skeletal muscle