Matthew W. Hulver, PhD


Department Head

Graduate Program Faculty

Co-Director, Center for Transformative Research on Health Behaviors

Molecular and Cellular Science
Clinical Physiology and Metabolism

Skeletal muscle substrate preference and metabolic flexibility; mechanistic signals for mitochondrial substrate selection; metabolic adaptation to changes in diet and physical activity or inactivity; etiology of skeletal muscle metabolic inflexibility in context of obesity, insulin resistance, and type 2 diabetes.

Isolation of Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High Throughput Microplate Respiratory Measurements. Boutagy NE, Pyne E, Rogers GW, Ali M, Hulver MW, Frisard MI.J Vis Exp. 2015 Nov 13;(105).

Using Isolated Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High throughput Microplate Respiratory Measurements.Boutagy NE, Rogers GW, Pyne ES, Ali MM, Hulver MW, Frisard MI.J Vis Exp. 2015 Oct 30;(105):e53216.

The effect of prebiotic supplementation with inulin on cardiometabolic health: Rationale, design, and methods of a controlled feeding efficacy trial in adults at risk of type 2 diabetes. Mitchell CM, Davy BM, Halliday TM, Hulver MW, Neilson AP, Ponder MA, Davy KP.Contemp Clin Trials. 2015 Nov;45(Pt B):328-37.

Probiotic supplementation attenuates increases in body mass and fat mass during high-fat diet in healthy young adults. Osterberg KL, Boutagy NE, McMillan RP, Stevens JR, Frisard MI, Kavanaugh JW, Davy BM, Davy KP, Hulver MW. Obesity (Silver Spring). 2015 Dec;23(12):2364-70.

Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet. Boutagy NE, Neilson AP, Osterberg KL, Smithson AT, Englund TR, Davy BM, Hulver MW, Davy KP. Obesity (Silver Spring). 2015 Dec;23(12):2357-63.

Short-term high-fat diet increases postprandial trimethylamine-N-oxide in humans. Boutagy NE, Neilson AP, Osterberg KL, Smithson AT, Englund TR, Davy BM, Hulver MW, Davy KP. Nutr Res. 2015 Oct;35(10)

Metabolic endotoxemia with obesity: Is it real and is it relevant? Boutagy NE, McMillan RP, Frisard MI, Hulver MW. Biochimie. 2015 Jun 29. pii: S0300-9084(15)00199-6.  

Selective overexpression of Toll-like receptor-4 in skeletal muscle impairs metabolic adaptation to high-fat feeding. McMillan RP, Wu Y, Voelker K, Fundaro G, Kavanaugh J, Stevens JR, Shabrokh E, Ali M, Harvey M, Anderson AS, Boutagy NE, Mynatt RL, Frisard MI, Hulver MW. Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1;309(3):R304-13.

Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance. Gao S, McMillan RP, Zhu Q, Lopaschuk GD, Hulver MW, Butler AA. Mol Metab. 2015 Jan 17;4(4):310-24  

HNFE 3025 Metabolic Nutrition
HNFE 4004 Seminar in Human Nutrition, Foods, and Exercise: Writing Discourse
HNFE 5134 Carbohydrate and Lipid Metabolism
ALS 5115/5984 Digestion and Energy Metabolism

American Diabetic Association

American Society of Nutrition

American Physiological Society

The Obesity Society

United Mitochondrial Disease Foundation

2004, Postdoctoral, Physiology, East Carolina University

2001, Ph.D., Exercise Physiology, University of Kansas

1998, M.S., Exercise Science, McDaniel College

1992, B.A., Fitness Management, Marietta College

Hulver, Matt



338-A Wallace Hall
Blacksburg, VA 24061

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