Siobhan Craige, PhD
Lifestyle modifications are key interventions for the prevention of cardiovascular and metabolic diseases. My research addresses critical questions in the regulation of cell signaling in response to nutrition and exercise. Specifically, my research program focuses on the endothelium, the monolayer of cells that lines the lumen of the vasculature. This specialized cell layer is responsible for rapidly reacting to changes in organ needs such as low nutrients or oxygen. The overall goal of my research program will be to elucidate the mechanisms by which diet and exercise influence pathways that dictate endothelial phenotype ultimately contributing to the prevention of cardio-metabolic disease.
Nam M, Akie TE, Sanosaka M, Craige SM, Kant S, Keaney JF Jr, Cooper MP. Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression. Sci Rep. 2017 May 17;7(1):2013.
Craiges SM*, Kroller-Schon S, Li C, Kant S, Cai S, Chen K, Contractor MM, Pei Y, Schulz E, Keaney JF. PGC-1a dictates endothelial function through regulation of eNOS expression. Sci Rep. 2016 Dec 2;6:38210. PMID: 27910955. *Corresponding Author
Dagdeviren S, Jung DY, Friedline RH, Noh HL, Kim JH, Patel PR, Tsitsilianos N, Inashima K, Tran DA, Hu X, Loubato ML, Craige SM, Kwon JY, Lee KW, Kim JK. Interleukin-10 Prevents Aging-Associated Inflammation and Insulin Resistance in Skeletal Muscle. FASEB J. 2017 Feb;31(2):701-710. Epub 2016 Nov 3. PMID: 27811060.
Craige SM, Reif MM, Kant S. Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states. Biochim Biophys Acta. 2016 Sep;1862(9):1581-6. PMID: 27259981. Review
Ramo K, Sugamura K, Craige SM, Keaney JF, Davis RJ. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife. 2016 Aug 9;5. pii: e18414. PMID: 27504807.
Zhang CH, Wang P, Liu DH, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Lu P, Zheng K, Craige SM, Lifshitz LM, Keaney JF Jr, Fogarty KE, ZhuGe R, Zhu MS. The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun. 2016 Apr 22;7:11358. PMID: 27101932.
Li C, Reif MM, Craige SM, Kant S, Keaney JF Jr. Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling. Nitric Oxide. 2016 May 1;55-56:45-53. PMID: 26989010.
Craige SM*, Kant S, Reif M, Chen K, Pei Y, Angoff R, Sugamura K, Fitzgibbons T, Keaney JF Jr. Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions. Free Radic Biol Med. 2015 Jul 10;89:1-7. PMID: 26169727. Commentary in Eur Heart J PMID: PMID: 26429798 *Corresponding Author
Craige SM*, Kant S, Keaney JF. Reactive oxygen species in endothelial function: From disease to adaptation. Circ J. 2015;79(6):1145-55. PMID: 25986771. Review *Corresponding Author
Craige SM*, Chen K, Pei Y, Li C, Huang X, Chen C, Shibata R, Sato K, Walsh K, Keaney JF Jr.. NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation. Circulation. 2011 Aug 9;124(6):731-40. PMID: 21788590. *Corresponding Author
Go YM*, Craige SM*, Orr M, Gernert KM, Jones DP. Gene and protein responses of human monocytes to extracellular cysteine redox potential. Toxicol Sci. 2009 Dec;112(2):354-62. *Authors contributed equally to this work.
Chen K, Craige SM, Keaney JF. Downstream Targets and Intracellular Compartmentalization in Nox Signaling. Antioxid Redox Signal. 2009. PMID: 19309256. Review
- Association for Women in Science, 2015-present
- American Society for Biochemistry and Molecular Biology, 2011-present
- Society of Free Radical Biology and Medicine, 2010-present
- American Heart Association, 2008-present
Oklahoma Nathan Shock Center Pilot Project Award, 2017
NIH National Research Service Award, Postdoctoral: 1F32HL099282 2010-2013
NIH National Research Service Award, Predoctoral: 2T32EY0070920-19 2001-2006
- Pilot Project Award, Oklahoma Nathan Shock Center of Excellence in the Biology of Aging to investigate redox changes in Nox4 with exercise, 2017
- National Research Service Award Recipient (NRSA) NHLBI 2010-2013
- Travel Award Winner, Society of Free Radical Biology and Medicine, Orlando FL, 2010
- Achievement Reward for College Scientists (ARCS) Fellowship, Emory University, 2005-2007
- Donald B. McCormick Award for Research Contributions to Nutrition, Emory University, 2005
2007, Ph.D., Emory University, Biochemistry
Thesis: Oxidative Stress in Aging and Age-Related Disease: Determinants of Plasma Cysteine and Glutathione Redox State
1999, B.S., Emory University, Biology