Robert W. Grange, PhD

Associate Professor, Associate Department Head

Graduate Program Faculty

Molecular and Cellular Science

Pathogenic mechanisms and treatments for Duchenne muscular dystrophy;  preclinical gene therapy to treat myotubular myopathy; muscle progenitors derived from inducible pluripotent stem cells to treat neuromuscular diseases; development of mathematical models of muscle function; exercise prescription to treat tendinopathies

Member, Muscle Group at Virginia Tech

Last five years:

KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy. Garg A, O'Rourke J, Long C, Doering J, Ravenscroft G, Bezprozvannaya S, Nelson BR, Beetz N, Li L, Chen S, Laing NG, Grange RW, Bassel-Duby R, Olson EN.J Clin Invest. 2014 Aug;124(8):3529-39

Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy. Liu N, Bezprozvannaya S, Shelton JM, Frisard MI, Hulver MW, McMillan RP, Wu Y, Voelker KA, Grange RW, Richardson JA, Bassel-Duby R, Olson EN.J Clin Invest. 2011 Aug;121(8):3258-68.  

Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6. Quiat D, Voelker KA, Pei J, Grishin NV, Grange RW, Bassel-Duby R, Olson EN.Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10196-201.

Compared with that of MUFA, a high dietary intake of n-3 PUFA does not reduce the degree of pathology in mdx mice. Henderson GC, Evans NP, Grange RW, Tuazon MA. Br J Nutr. 2014 Feb 13:1-10.

Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy. Childers MK, Joubert R, Poulard K, Moal C, Grange RW, Doering JA, Lawlor MW, Rider BE, Jamet T, Danièle N, Martin S, Rivière C, Soker T, Hammer C, Van Wittenberghe L, Lockard M, Guan X, Goddard M, Mitchell E, Barber J, Williams JK, Mack DL, Furth ME, Vignaud A, Masurier C, Mavilio F, Moullier P, Beggs AH, Buj-Bello A. Sci Transl Med. 2014 Jan 22;6(220):220ra10.  

Myosin phosphorylation and force potentiation in skeletal muscle: evidence from animal models. Vandenboom R, Gittings W, Smith IC, Grange RW, Stull JT. J Muscle Res Cell Motil. 2013 Dec;34(5-6):317-32. doi: 10.1007/s10974-013-9363-8. Epub 2013 Oct 27.

Selenoprotein N deficiency in mice is associated with abnormal lung development. Moghadaszadeh B, Rider BE, Lawlor MW, Childers MK, Grange RW, Gupta K, Boukedes SS, Owen CA, Beggs AH. FASEB J. 2013 Apr;27(4):1585-99.  

Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with X-linked myotubular myopathy. Lawlor MW, Armstrong D, Viola MG, Widrick JJ, Meng H, Grange RW, Childers MK, Hsu CP, O'Callaghan M, Pierson CR, Buj-Bello A, Beggs AH. Hum Mol Genet. 2013 Apr 15;22(8):1525-38.

Muscle function in a canine model of X-linked myotubular myopathy. Grange RW, Doering J, Mitchell E, Holder MN, Guan X, Goddard M, Tegeler C, Beggs AH, Childers MK. Muscle Nerve. 2012 Oct;46(4):588-91.  

Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2. Shi X, Wallis AM, Gerard RD, Voelker KA, Grange RW, DePinho RA, Garry MG, Garry DJ. J Cell Sci. 2012 Nov 15;125(Pt 22):5329-37.  

Exercise and Duchenne muscular dystrophy: where we have been and where we need to go. Markert CD, Case LE, Carter GT, Furlong PA, Grange RW. Muscle Nerve. 2012 May;45(5):746-51.

HNFE 3804 Exercise Physiology

HNFE 4004 Writing and Discourse

HNFE 4844 Exercise and Neuromuscular Performance

HNFE 5984 Fundamentals of Neuromuscular Control

HNFE 6024 Topics in Molecular Cell and Biotechnology

1993, Ph.D., Kinesiology, University of Waterloo
1984, M.S., Kinesiology, University of Washington
1979, B.S., Physical Education, University of British Columbia

Grange Robert

540-231-2725
rgrange@vt.edu

HNFE
1981 Kraft Drive
1029 ILSB
Blacksburg, VA 24060

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