Deborah J. Good, PhD

Associate Professor

Graduate Program Faculty

Molecular and Cellular Science

Role of bHLH transcription factors in hypothalamic gene expression, especially in the regulation of body weight, exercise, and motivation

Use of transgenic and knockout animals, and phylogenetic analysis of gene and allele evolution, as these relate to body weight control and human health

Last five years:

Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).Al Rayyan N, Zhang J, Burnside AS, Good DJ.Mol Cell Endocrinol. 2014 Mar 25;384(1-2):134

MicroRNA signature obtained from the comparison of aggressive with indolent non-Hodgkin lymphomas: potential prognostic value in mantle-cell lymphoma. Goswami RS, Atenafu EG, Xuan Y, Waldron L, Reis PP, Sun T, Datti A, Xu W, Kuruvilla J, Good DJ, Lai R, Church AJ, Lam WS, Baetz T, Lebrun DP, Sehn LH, Farinha P, Jurisica I, Bailey DJ, Gascoyne RD, Crump M, Kamel-Reid S. J Clin Oncol. 2013 Aug 10;31(23):2903-11.

NHLH2: at the intersection of obesity and fertility. Good DJ, Braun T. Trends Endocrinol Metab. 2013 Aug;24(8):385-90. doi: 10.1016/j.tem.2013.04.003. Epub 2013 May 17. PMID: 23684566

Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding. Al Rayyan N, Wankhade UD, Bush K, Good DJ. Gene. 2013 Jan 1;512(1):134-42.  

Preventive effects of conjugated linoleic acid on obesity by improved physical activity in nescient basic helix-loop-helix 2 knockout mice during growth period. Kim JH, Gilliard D, Good DJ, Park Y. Food Funct. 2012 Dec;3(12):1280-5.

Dietary conjugated nonadecadienoic acid prevents adult-onset obesity in nescient basic helix-loop-helix 2 knockout mice. Kim JH, Park Y, Kim D, Good DJ, Park Y. J Nutr Biochem. 2013 Mar;24(3):556-66. doi: 10.1016/j.jnutbio.2012.02.005. Epub 2012 Jul 20. PMID: 22819563

Extending the reach of Exendin-4: new pathways in the control of body weight and glucose homeostasis. Good DJ. Endocrinology. 2012 May;153(5):2051-3. doi: 10.1210/en.2012-1149. No abstract available. PMID: 22523329

Comparison of hypothalamic mRNA levels in mice euthanized by CO₂ inhalation and focused-beam microwave irradiation. Zhang H, Good DJ. Lab Anim (NY). 2011 Sep 21;40(10):313-8. doi: 10.1038/laban1011-313. PMID: 22358208

Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2.Wankhade UD, Good DJ. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):39-47.  

Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability. Vella KR, Burnside AS, Brennan KM, Good DJ. J Neuroendocrinol. 2007 Jul;19(7):499-510.

Mitigating or exacerbating effects of maternal-fetal programming of female mice through the food choice environment. Brenseke B, Bahamonde J, Talanian M, Kornfeind E, Daly J, Cobb G, Zhang J, Prater MR, Davis GC, Good DJ. Endocrinology. 2015 Jan;156(1):182-92.

HNFE 3026 Metabolic Nutrition II
HNFE 4004 Seminar in HNFE Writing and Discourse
HNFE 4984 Cells to Society Journal Club
HNFE 4984 USDA Scholars Program
GRAD 5984 Professional Development

1997, Postdoctoral Scholar, Molecular Neuroendocrinology, NIH and NCI
1992, Ph.D., Molecular and Cellular Biology, Northwestern University
1987, B.S., Biomedical Research, SUNY College at Fredonia

540-231-0430
goodd@vt.edu

HNFE
1981 Kraft Drive
1020 ILSB
Blacksburg, VA 24060

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