David A. Brown, PhD
Graduate Program Faculty
Virginia Tech Faculty of Health Sciences
Member, Virginia Tech Center for Drug Discovery
Clinical Physiology and Metabolism
Molecular and Cellular Science
Dave Brown directs a laboratory that combines disciplines in cardiac physiology and mitochondrial biology. His lab uses approaches in intact hearts, isolated cardiac myocytes, permeabilized ventricular fibers, and isolated mitochondria to gain multi-level insight into cardiac physiology in health and disease. His work has been well received in the scientific community, reflected by numerous extramural grant awards, a consistent publication history, and several scientific awards.
Mitochondrial function as a therapeutic target in heart failure. David A. Brown, Justin B. Perry, Mitchell E. Allen, Hani N. Sabbah, Brian L. Stauffer, Saame Raza Shaikh, John G.F. Cleland, Wilson S. Colucci, Javed Butler, Adriaan A. Voors, Stefan D. Anker, Bertram Pitt, Burkert Pieske, Gerasimos Fillipatos, Stephen J. Greene, and Mihai Gheorghiade.Nature Reviews Cardiology 2017 (PMID 28004807)
Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA. American journal of physiology. Heart and circulatory physiology. 2016; 310(10):H1360-70.
Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart. Shi J, Dai W, Hale SL, Brown DA, Wang M, Han X, Kloner RA.Life sciences. 2015; 141:170-8.
Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment. McClung JM, Reinardy JL, Mueller SB, McCord TJ, Kontos CD, Brown DA, Hussain SN, Schmidt CA, Ryan TE, Green TD. Frontiers in physiology. 2015; 6:161.
Mitochondrial Regulation of the Muscle Microenvironment in Critical Limb Ischemia. Ryan TE, Schmidt CA, Green TD, Brown DA, Neufer PD, McClung JM. Frontiers in physiology. 2015; 6:336.
Increasing mitochondrial membrane phospholipid content lowers the enzymatic activity of electron transport complexes. Shaikh SR, Sullivan EM, Alleman RJ, Brown DA, Zeczycki TN. Biochemistry. 2014; 53(35):5589-91.
Increasing levels of cardiolipin differentially influence packing of phospholipids found in the mitochondrial inner membrane. Zeczycki TN, Whelan J, Hayden WT, Brown DA, Shaikh SR. Biochemical and biophysical research communications. 2014; 450(1):366-71.
"Roid-Rage" at the cellular level: abolition of endogenous cardioprotection by anabolic steroids reveals new links between the RAAS and cardiac KATP channels : editorial to: "AT1 and aldosterone receptors blockade prevents the chronic effect of nandrolone on the exercise-induced cardioprotection in perfused rat heart subjected to ischemia and reperfusion" by S.R. Marques-Neto et al. Chicco AJ, Brown DA. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 2014; 28(2):113-4.
Pulmonary instillation of multi-walled carbon nanotubes promotes coronary vasoconstriction and exacerbates injury in isolated hearts. Thompson LC, Frasier CR, Sloan RC, Mann EE, Harrison BS, Brown JM, Brown DA, Wingard CJ. Nanotoxicology. 2014; 8(1):38-49. NIHMSID: NIHMS574358
American Heart Association (Council on Basic Cardiovascular Sciences)
American Physiological Society
Mitochondrial Physiology (MiP) Society
- Teaching Recognition Award, Brody School of Medicine Class of 2018. Recognized for "demonstrated commitment to teaching students." May 7, 2015
- Best Lecture Series, Brody School of Medicine Class of 2018.
- Excellence in Teaching Award, Brody School of Medicine Class of 2016. Recognized "for demonstrated commitment to teaching students." May 2013
- Best Lecturer Award, Brody School of Medicine Class of 2016. Recognized "for the most informative, well-delivered series of lectures during the first year, preparing medical students for course exams, shelf exams, and a lifetime in medicine." April 2013. Also nominated for this award in April 2014 by the Class of 2017.
- Best Lecture Series in the Basic Sciences Award, Brody School of Medicine Class of 2015. Recognized "for the most informative, well-delivered series of lectures during the first two years, preparing medical students for course exams, shelf exams, and a lifetime in medicine" April 2013. Also nominated for this award in April 2014 by the Class of 2016.
- Teaching Recognition Award, Brody School of Medicine Class of 2014. Recognized for "demonstrated commitment to teaching medical students." Received award after teaching class for first time. May 2011.
- “Best Should Teach” Award; University of Colorado Graduate Teacher Program, 2004
- Health Sciences Author Recognition Award from the Laupus Library, Brody School of Medicine. Greenville, NC, November, 2010-2013.
- Gatorade Young Investigator Award from the Environmental and Exercise Physiology Section of the American Physiological Society – Awarded April 2005, San Diego CA.
- Research Recognition Award from the Cardiovascular Section of the American Physiological Society – Awarded April 2004, Washington D.C.
- Mr. and Mrs. J. Tour Scholar at the University of Colorado at Boulder (Fall 2005)
- Beverly Sears Graduate Student Grant Award – Spring 2003
- University of Colorado Graduate Student Travel Grant Recipient – Spring 2003
2006-2008, Postdoctoral Fellow, Institute of Molecular Cardiobiology, Johns Hopkins University
2005, Ph.D., Integrative Physiology, University of Colorado at Boulder
Dissertation: Myocardial ATP-sensitive K+ Channels and Ischemia/Reperfusion Injury
1999, B.S., Human Nutrition, Foods, and Exercise, Virginia Tech