Eva Maria Schmelz

Associate Professor

1983    M.S., Human Nutrition, Justus-Liebig University, Giessen, Germany;

1992    Ph.D., Nutrition, Human Biology Justus-Liebig University, Giessen, Germany;

1992-1996    Postdoctoral Training Emory University, Atlanta, GA,

Research

Chemopreventive and chemotherapeutic uses of natural and synthetic sphingolipid metabolites, sphingolipid metabolism and sphingolipid-mediated signal transduction pathways in normal epithelial and cancer cells, regulation of aberrant gene expression in cancer cells by non-toxic concentrations of sphingolipid metabolites.

Publications

Ketene, A.N., Schmelz, E.M., Roberts, P.C., and Agah, M. (2012) The effects of cancer progression on the viscoelasticity of ovarian cell cytoskeleton structures. Nanomedicine 8: 93-102.

Babahosseini, H., Schmelz, E.M., Roberts, P.C., Agah, M. Roles of bioactive sphingosine in ovarian cancer cell biomechanics. Proceedings of the 2nd IEEE Conference on Applied Bionics and Biomechanics (ICABB-2012).

Roberts, P.C. and Schmelz, E.M. In vitro model of spontaneous mouse OSE transformation. Methods in Molecular Biology, Humana Press, 2012

Salmanzadeh A, Kittur H, Sano MB, Roberts PC, Schmelz EM, Davalos RV. Dieectrophoretic differentiation of mouse ovarian surface epithelial cells, macrophages, and fibroblasts using contactless dielectrophoresis.Biomicrofluidics. 2012 Jun;6(2):24104-2410413. Epub 2012 Apr 3.

Ketene AN, Roberts PC, Shea AA, Schmelz EM, Agah M. Actin filaments play a primary role for structural integrity and viscoelastic response in cells.Integr Biol (Camb). 2012 May;4(5):540-9. Epub 2012 Mar 26.

Sano MB, Henslee EA, Schmelz E, Davalos RV. Electrophoresis. Contactless dielectrophoretic spectroscopy: examination of the dielectric properties of cells found in blood.2011 Nov;32(22):3164-71. doi: 10.1002/elps.201100351.

Henslee EA, Sano MB, Rojas AD, Schmelz EM, Davalos RV. Selective concentration of human cancer cells using contactless dielectrophoresis.Electrophoresis. 2011 Sep;32(18):2523-9. doi: 10.1002/elps.201100081. Epub 2011 Aug 26.

Dai Y, Hogan S, Schmelz EM, Ju YH, Canning C, Zhou K. Selective growth inhibition of human breast cancer cells by graviola fruit extract in vitro and in vivo involving down regulation of EGFR expression.Nutr Cancer. 2011;63(5):795-801. Epub 2011 Jun 22.

Ketene AN, Schmelz EM, Roberts PC. The effects of cancer progression on the viscoelasticity of ovarian cell cytoskeleton structures.Agah M. Nanomedicine. 2012 Jan;8(1):93-102. Epub 2011 Jun 23.

Creekmore AL, Silkworth WT, Cimini D, Jensen RV, Roberts PC, Schmelz EM. Changes in gene expression and cellular architecture in an ovarian cancer progression model.. PLoS one. 2011 Mar 3;6(3):e17676.

Mazzei JC, Zhou H, Brayfield BP, Hontecillas R, Bassaganya-Riera J, Schmelz EM. Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor γ expression.J Nutr Biochem. 2011 Dec;22(12):1160-71. Epub 2011 Feb 4.

Nikkhah M, Strobl JS, Schmelz EM, Agah M. Evaluation of the influence of growth medium composition on cell elasticity.J Biomech. 2011 Feb 24;44(4):762-6. Epub 2010 Nov 24.

Ventrella-Lucente LF, Unnikrishnan A, Pilling AB, Patel HV, Kushwaha D, Dombkowski AA, Schmelz EM, Cabel of DC, Heydari AR. Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice.J Biol Chem. 2010 Jun 18;285(25):19246-58. Epub 2010 Apr 19.

Evans NP, Misyak SA, Schmelz EM, Guri AJ, Hontecillas R, Bassaganya-Riera J. Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma.J Nutr. 2010 Mar;140(3):515-21. Epub 2010 Jan 20.

Simon KW, Tait L, Miller F, Cao C, Davy KP, LeRoith T, Schmelz EM. Suppression of breast xenograft growth and progression in nude mice: implications for the use of orally administered sphingolipids as chemopreventive agents against breast cancer.Food Funct. 2010 Oct;1(1):90-8. Epub 2010 Sep 23.

Simon KW, Roberts PC, Vespremi MJ, Manchen S, Schmelz EM. Regulation of beta-catenin and connexin-43 expression: targets for sphingolipids in colon cancer prevention.Mol Nutr Food Res. 2009 Mar;53(3):332-40.

Additional Information

1997-1999    Assistant Professor, R.T., Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia

1999-2006    Assistant Professor, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI

2005-2007    Faculty member of the Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI

2006-2007    Associate Professor, Dept. of Nutrition and Food Science, Wayne State University, Detroit, MI

2006-2007    Adjunct Associate Professor, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI

4/2007-        Associate Professor, Dept. of Human Nutrition, Foods and Exercise, Institute of Biomedical and Public Health Sciences, Virginia Polytechnic Institute and University, Blacksburg, VA

8/2008-        Faculty member, Post-DVM training program on Animal Model Research for Veterinarians, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and University, Blacksburg, VA