Eva Maria Schmelz

Associate Professor

1983    M.S., Human Nutrition, Justus-Liebig University, Giessen, Germany;

1992    Ph.D., Nutrition, Human Biology Justus-Liebig University, Giessen, Germany;

1992-1996    Postdoctoral Training Emory University, Atlanta, GA,

Research

Chemopreventive and chemotherapeutic uses of natural and synthetic sphingolipid metabolites, sphingolipid metabolism and sphingolipid-mediated signal transduction pathways in normal epithelial and cancer cells, regulation of aberrant gene expression in cancer cells by non-toxic concentrations of sphingolipid metabolites.

Publications

Simon, K.W., Roberts, P.C., Vespremi, M.J., Manchen, S.T., and Schmelz, E.M. (2009) Regulation of ß-catenin and connexin-43 expression by sphingolipids: Importance for colon cancer prevention. Mol. Nutr Food Res. 53: 332-340. e-published Oct 2008.

Schmelz, E.M., Xu, H., Sengupta, R., Du, J., Bannerjee, S., Sarkar, F.H., Rishi, A.K., and Majumdar, A.P. (2007) Regression of Early and Intermediate Stages of Colon Cancer by Targeting Multiple Members of the EGFR Family with EGF-Receptor Related Protein. Cancer Res. 67: 5389-5396.

Schmelz, E.M, Wang, D.M. and Merrill, A.H., Jr. (2006) Genomics, Proteomics, Metabolomics and Systems Biology approaches to Nutrition. In: Ziegler, EE. and Filer, L.J. (eds.): Present Knowledge in Nutrition, 9th edition, pp 3-19, ILSI Press, Washington, D.C.

Schmelz E.M. and Symolon, H. (2006) Sphingolipids and cancer. In: Hirabayashi, Y., Igarashi, Y., Merrill, A.H., Jr. (eds) Sphingolipid Biology, pp 363-379, Springer Verlag-Tokio, Germany/ Japan.

Schmelz E.M. (2006) Sphingolipids as Chemopreventive Agents. In: Awad, A.B. and Bradford, P.G. (eds.) Nutrition and Cancer Prevention, pp 519-538, Taylor and Francis, Boca Raton, London, New York.

Roberts, P.C., Mottillo , E.P., Baxa , A., Heng, H.H.Q., Doyon-Reale, N., Gregoire, L., Lancaster, W.D., Rabah, R., and Schmelz, E.M. (2005) Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model. Neoplasia 7: 944-956.

Additional Information

1997-1999    Assistant Professor, R.T., Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia

1999-2006    Assistant Professor, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI

2005-2007    Faculty member of the Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI

2006-2007    Associate Professor, Dept. of Nutrition and Food Science, Wayne State University, Detroit, MI

2006-2007    Adjunct Associate Professor, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI

4/2007-        Associate Professor, Dept. of Human Nutrition, Foods and Exercise, Institute of Biomedical and Public Health Sciences, Virginia Polytechnic Institute and University, Blacksburg, VA

8/2008-        Faculty member, Post-DVM training program on Animal Model Research for Veterinarians, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and University, Blacksburg, VA