The research focus in the Hulver Laboratory is to better understand the nutritional signals that contribute to dysregulated skeletal muscle substrate metabolism in disease states such as obesity, type 2 diabetes, and cancer. More specifically, we are studying the role of pro-inflammatory pathways in skeletal muscle lipid accumulation and how the activity of these pathways is exacerbated by over-nutrition.
Goodrich KM, Fundaro G, Griffin LE, Grant A, Hulver MW, Ponder MA, Neilson AP. Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats. Nutr Res. 2012 Oct;32(10):787-94. doi: 10.1016/j.nutres.2012.09.004. Epub 2012 Oct 15.
Yang Z, Hulver MW, McMillan RP, Cai L, Kershaw EE, Yu L, Xue B, Shi H. Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3).PLoS One. 2012;7(10):e47493. doi: 10.1371/journal.pone.0047493. Epub 2012 Oct 24.
Carrer M, Liu N, Grueter CE, Williams AH, Frisard MI, Hulver MW, Bassel-Duby R, Olson EN. Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378.Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15330-5. Epub 2012 Sep 4.
Jiao Y, George SK, Zhaoq Q, Hulver MW, Hutson SM, Bishop CE, Lu B. Mex3c mutation reduces adiposity and increases energy expenditure.Mol Cell Biol. 2012 Aug 27. [Epub ahead of print]
Murali G, Milne GL, Webb CD, Stewart AB, McMillan RP, Lyle BC, Hulver MW, Saraswathi V. Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR -/- mice.J Lipid Res. 2012 Oct;53(10):2186-97. Epub 2012 Jul 29.
Wearn JG, Suagee JK, Crisman MV, Corl BA, Hulver MW, Hodgson DR, Geor RJ, McCutcheon LJ. Effects of the insulin sensitizing drug, pioglitazone, and lipopolysaccharide administration on markers of systemic inflammation and clinical parameters in horses.Vet Immunol Immunopathol. 2012 Jan 15;145(1-2):42-9. Epub 2011 Oct 25.
Potteiger JA, Claytor RP, HulverMW, Hughes MR, Carper MJ, Richmond S, Thyfault JP. Resistance exercise and aerobic exercise when paired with dietary energy restriction both reduce the clinical components of metabolic syndrome in previously physically inactive males.Eur J Appl Physiol. 2012 Jun;112(6):2035-44. Epub 2011 Sep 23.
Suagee JK, Corl BA, Hulver MW, McCutcheon LJ, Geor RJ. Effects of hyperinsulinemia on glucose and lipid transporter expression in insulin-sensitive horses.Domest Anim Endocrinol. 2011 Apr;40(3):173-81. Epub 2010 Dec 28
Flack KD, Davy KP, Hulver MW, Winett RA, Frisard MI, Davy BM. Aging, resistance training, and diabetes prevention.J Aging Res. 2010.
Civitarese AE, MacLean PS, Carling S, Kerr-Bayles L, McMillan RP, Pierce A, Becker TC, Moro C, Finlayson J, Lefort N, Newgard CB, Mandarino L, Cefalu W, Walder K, Collier GR, Hulver MW, Smith SR, Ravussin E. Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.Cell Metab. 2010 May 5;11(5):412-26.
Bell JA, Reed MA,Consitt LA, Martin OJ, Haynie KR, Hulver MW, Muoio DM, Dohm GL. J Clin Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression.Endocrinol Metab. 2010 Jul;95(7):3400-10. Epub 2010 Apr 28.
Consitt LA, Bell JA, Koves TR, Muoio DM, Hulver MW, Haynie KR, Dohm GL, Houmard JA. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals. Diabetes. 2010 Jun;59(6):1407-15. Epub 2010 Mar 3.
Frisard MI, McMillan RP, Marchand J, Wahlberg KA, Wu Y, Voelker KA, Heilbronn L, Haynie K, Muoio B, Li L, Hulver MW. Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab.2010 May;298(5):E988-98. Epub 2010 Feb 23.