Deborah J Good

Associate Professor

Research

Role of bHLH transcription factors in hypothalamic gene expression, especially in the regulation of body weight, exercise and motivation; the use of transgenic and knockout animals, and phylogenetic analysis of gene and allele evolution, as these relate to body weight control and human health.

Publications

Good, D.J., McIntyre, C.M., and Marchant, M.A. (2012) The USDA Scholars Program:  Innovations in a Summer Undergraduate Research Program, NACTA Journal, accepted.

Kim, J-H, Park, Y., Kim, D., Good, D.J.and Park, Y., (2012) Dietary Conjugated Nonadecadienoic Acid Prevents Adult-onset Obesity in Nescient Basic Helix-Loop-Helix 2 Knockout Mice, J. Nutritional Biochemistry, in press

Kim, J-H., Gilliard, D., Good, D.J., and Park, Y., (2012) Preventive effects of conjugated linoleic acid on obesity by improved physical activity in nescient basic helix-loop-helix 2 knockout mice during growth period, Food and Function, 3: 1280-1285.

Al_Rayyan, N., Wankhade, U.D., Bush, K., and Good, D.J. (2012) Two Single Nucleotide Polymorphisms in the Human Nescient Helix Loop Helix 2 (NHLH2) Gene Reduce mRNA Stability and DNA Binding, Gene, 512: 134-142.

Good, D.J. (2012) Extending the Reach of Exendin-4: New Pathways in the Control of Body Weight and Glucose Homeostasis, Endocrinology, 153: 2051-2053, and impact factor 5.1.

Davis, G., Jacob J. and Good, D.J. (2012) Effects of Price and Genetics on Food Choices and Obesity-Related Phenotypes in Mice, Open Neuroendocrinology Journal, 5:13-21 (Open source journal)

Wankhade, U.D. and Good, D.J. (2011) Melanocortin 4 Receptor is a Transcriptional Target of Nescient Helix-Loop-Helix-2, Molecular and Cellular Endocrinology, 341: 39-47, PubMed, impact factor 4.1

Zhang, H. and Good, D.J. (2011) Comparison of Hypothalamic mRNA Levels in Animals Euthanized by CO2 Asphyxiation or Focused-Beam Microwave Irradiation, Lab Animal,40: 313-318, impact factor 0.6

Boyle, K. J., Davis, G., Estabrooks, P.A., Good, D.J., King-Casas, B., Marathe, A., and You, W. (2011) Translational Economics Research, Association of Environmental and Resource Economists, 31(1):  16-25.

Wankhade, U. D., Vella, K.R., Fox, D. L., and Good, D.J. (2010) Deletion of Nhlh2 Results in a Defective Torpor Response and Reduced Beta Adrenergic Receptor Expression in Adipose Tissue, PlosOne Biology, 5(8). pii: e12324, PubMed, impact factor 4.4,

Good, D.J., (2010) Examining Polymorphisms Affecting Transcription and Translation of Genes Linked to Marbling in Beef Cattle, Animal Genetics, Rechi, L.J. Ed, Nova Scientific Publishers, ISBN 978-1-60741-844-3, chapter 7 Amazon.com link

Good, D.J. (2010) Transcriptional Regulation of Energy Availability Sensing Within Hypothalamic Neurons, Open Neuroendorinol. J., Vol. 3, 1-5. (Open source journal)

Vella, K.R., and Good, D.J. (2010) Nhlh2 is a Cold-Responsive Gene, Open Neuroendorinol. J. Vol 3, 38-44. (Open source journal)

Hur, S.J., Whitcomb, F., Rhee, S., Park, Y., Good, D.J.and Park, Y. (2009) Effects of trans-10, cis-12 conjugated linoleic acid on body composition in genetically obese mice. J. Medicinal Food, 12(1): 56-63,PubMed, impact factor 1.342

Good, D.J., Coyle, C.A., and Fox, D.L. (2008) Nhlh2:  A basic helix-loop-helix transcription factor controlling physical activity. Exercise and Sports Science Reviews, 36: 187-192 PubMed, impact factor 2.983

Coyle, C.A., Strand, S. C., and Good, D.J. (2008) Reduced physical activity contributes to obesity in Tub Mutant Mice, Physiology and Behavior, 95 (1-2): 168-175 PubMed, impact factor 2.561

Fox, D.L. and Good, D.J.(2008) Nhlh2 Interacts with STAT3 to Regulate Transcription of Prohormone Convertase 1/3, Molecular Endocrinology, 22 (6): 1438-1448 PubMedimpact factor 5.337

Good, D.J. (2008) "Mouse Models of Obesity and Overweight," in "Sourcebook of Models for Biomedical Research," Humana Press. Totowa, NJ pp 683-702. ISBN: 978-1-58829-933-8 Publisher's Link, Amazon.com link

Jing, E., Nillni, E.A., Sanchez, V.C., Stuart, R. and Good, D.J. (2004) Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides M.S.H and TRH and implicates prohormone convertases I and II in obesity, Endocrinology 145:1503-1513. PubMed, impact factor 5.045

Vella, K.R., Burnside, A.S. Brennan, K.A. and Good, D.J. (2007) Expression of the Hypothalamic Transcription Factor Nhlh2 is Dependent on Energy Availability, J. Neuroendocrinology, 19: 499-510 PubMed, impact factor 2.588

Fox, D.L., and Good, D.J. (2008) Nhlh2 interacts with Stat3 to regulate transcription of Prohormone Convertase 1/3. Molecular Endocrinology, 22 (6): 1438-1448 PubMed, impact factor 5.337

Good, D.J.(2007) "Mouse Models of Obesity and Overweight", in "Sourcebook of Models for Biomedical Research," Humana Press. Totowa, NJ pp 683-702. Publisher's Link, Amazon.com

Fox, D. L., Vella, K.R., and Good, D.J. (2007) "Energy Balance Pathways Converging on the Nhlh2 Transcription Factor", in Frontiers in Bioscience, Peptides Controlling Energy Balance, 12: 3983-3993 Publisher's Link, PubMed, impact factor 3.760

Good, D.J.,Coyle, C.A., and Fox, D.L. (2008) Nhlh2:  A basic helix-loop-helix transcription factor controlling physical activity. Exercise and Sports Science Reviews, 36: 187-192 PubMed, impact factor 2.983

Coyle, C.A., Strand, S. C., and Good, D.J. (2008) Reduced physical activity contributes to obesity in Tub Mutant Mice, Physiology and Behavior, 95 (1-2): 168-175 PubMed, impact factor 3.298

Good, D.J. (2010) Transcriptional Regulation of Energy Availability Sensing Within Hypothalamic Neurons, Open Neuroendorinol. J., Vol. 3, 1-5.

Vella, K.R. and Good, D.J. (2010) Nhlh2 is a Cold-Responsive Gene, Open Neuroendocrinol. J. Vol 3, 38-44.